I have been trying to find information on this peptide all day. I went through a lot of posts from all different boards and peptide suppliers. The info I have gained says that there is not enough data available yet to say how effective this peptide is. If anyone can provide some research, studies, real life experiments that would be great! Here is some of the info I gathered.
(From various posts and peptide suppliers)
The HGH Fragment is a modified form (Figure 1) of amino acids 176-191 at the C-terminal region of growth hormone.
Investigators at Monash University discovered that the fat-reducing effects of GH appear to be controlled by a small region near one end of the GH molecule. This region, which consists of amino acids 176-191, is less than 10% of the total size of the GH molecule and appears to have no effect on growth or insulin resistance. It works by mimicking the way natural hGH regulates fat metabolism but without the adverse effects on blood sugar or growth that is seen with unmodified hGH. Like unmodified GH, the HGH fragment 176-191 stimulates lipolysis and inhibits lipogenesis both in laboratory testing and in animals and humans. The HGH fragment does not appear to affect appetite.
In laboratory tests on fat cells from rodents, pigs, dogs, and humans, the HGH fragment released fat specifically from obese fat cells but not from lean ones, reduced new fat accumulation in all fat cells, enhanced the burning of fat. In rodents (rats and mice), HGH fragment reduced body fat in obese animals but, enhanced fat burning without changing food consumption or inducing growth (as it does not increase IGF levels) or any other unwanted hGH effect.
The (HGH fragment 176-191) is a stabilized analogue of the growth hormone-releasing factor (GRF) that induces growth hormone (GH) in a specific and physiological manner. To date studies suggest that (HGH fragment 176-191) has several beneficial features: it reduces abdominal fat (in particular visceral fat), without compromising glycemic control (blood glucose), it increases muscle mass and improves the lipid profile. These characteristics make it an ideal candidate for the treatment of excess abdominal fat, an important aspect of HIV-associated lipodystrophy.
At a dosage of 500mcg the (HGH fragment 176-191) was shown to increase lipolytic activity in adipose tissue. In other words this fragment potently burns body fat, especially stubborn adipose body fat, and it does so potently! Of significance, is that the fragment has no negative impact on insulin sensitivity, a stark contrast from its Human Growth Hormone counterpart.(Ng FM, Sun J,Sharma L, Libinaka R, Jiang WJ, and Gianello R 2000).
Not only does the (HGH fragment 176-191) not interfere with the bodyâs natural insulin regulation as Human Growth Hormone can, the (HGH fragment 176-191) does not result in cellular proliferation as Human Growth Hormone does. The fragment is similar to Human Growth Hormone, hence the shared amino acid sequence, however, the (HGH fragment 176-191) does not induce hyperglycaemia or reduce insulin secretion. The (HGH fragment 176-191) does not compete for the hGH receptor and nor does it induce cell proliferation, unlike Human Growth Hormone. (Wu Z, Ng FM. 1993). Thusly,%
(Mostly from Datbtrue)
What I have gathered is you want to take this peptide on an empty stomach because HGH Frag 176 will mobilize fatty acids. IF you are trying to lose fat, you do not want insulin to be active while GH is active or else you won’t lose much fat. In addition you want to make use of the newly mobilized fatty acids so cardio/activity is beneficial. HGH Frag 176-191 is the lipolytic/anti-lipogenic domain of intact hGH.the fragment with the amino acid sequence (176-191) is 56% more bioactive then the fragment with the amino acid sequence (177-191).
So there is mixed opinions on this peptide and maybe because a lot of people used HGH frag 177 and not 176, or they dosed it too low. Proper dosage is around 400mcg-2000mcg daily split into 3 doses a day preferably on an empty stomach to get the best results due to insulin not being active. I would also say that a dose should be administered about 30 minutes before weight lifting or cardio so that you can utilize the fat burning effects. Another good time would be first thing in the morning about 1 hour or so before eating breakfast.